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Fecal transplants can be life-saving for people with stubborn bacterial infections, but they're not regarding the faint of center. So doctors have arrive up with a method to create them more palatable – the frozen poop capsule. People infected with Clostridium difficile suffer debilitating diarrhea, but the bug usually defies antibiotics. Doctors have got recently discovered that the fecal transplant will bring back good gut bacteria that will banishes the C. difference. But the procedure is usually awkward, requiring a gift of fresh feces, generally from a relative, and also a colonoscopy to deliver this. Researchers at Massachusetts Common Hospital figured they can improve on that. Very first they tried delivering the particular fecal transplant by way of a pipe snaked down the nasal area and into the abdomen. It delivered the healthful bugs, but wasn't a lot fun. Billie Iverson, eighty six, of Cranston, R. I actually., recently underwent a transplant of intestinal microbes that likely saved her life. Shots - Health News Microbe Transplants Treat Some Diseases That Drugs Can't Fix "Just getting the tube down is a problem, " Dr. Elizabeth Hohmann, a staff physician in infectious diseases at Mass General, told Shots. And the doctors worried that if people gagged and vomited, they could inhale fecal matter. "That's pretty scary. " Enter the poop pill. A pill wouldn't require invasive procedures, the researchers speculated, and would be less likely to cause vomiting. And if they froze they pills, donors wouldn't need to be standing by. To test that hypothesis, the researchers got donations from young, healthy volunteers screened to make sure they didn't have HIV, hepatitis or other infectious diseases. They froze the material and waited four weeks to test the donors again. Once the donors got a clean bill of health, pill production began. By now you're probably wondering what a poop pill looks like. "When I first started doing this I had in my mind that it would be a little red-and-white banded capsule, like a Tylenol capsule, " Hohmann says. "That was my dream. " But alas, the capsules had to be acid-resistant so they could make their way past the stomach into the large intestine, where the good microbes work their magic. And acid-resistant capsules only come in translucent. "So they are kind of brownish-colored capsules, " Hohmann says. "Fortunately, because could possibly be frozen, when you consider them out from the refrigerator they sort of ice up a bit plus they're not too major. " Bad bug: The particular bacterium Clostridium difficile eliminates 14, 000 people within the United States every year. Shots - Wellness News FDA Backs Away from On Regulation Of Waste Transplants Twenty people along with recurrent C. diff bacterial infections took 15 pills the day, about the dimension of the large multivitamin, regarding two days. Fourteen associated with them were without any diarrhea almost immediately, without recurrences. The other six attempted the treatment again; that will worked for four associated with them. The 2 people who else failed to get outcome was in poorer health general, the study found. Yet the treatment worked regarding people from age eleven to age 89. The particular Mass General group provides since treated another twenty one people with the supplements, with similar success. The particular results were announced Saturday at the IDWeek meeting in Philadelphia and published in JAMA, the journal of the American Medical Association. "We're really jazzed that a journal of this stature has picked this up, " Hohmann says. "I've been a microbiology researcher for 25 years and this is the biggest thing we've done. " Have you been published in JAMA before? "Oh no, no, never. " Despite the impressive results, poop pills may turn out to be not the silver bullet they seem today. Though the treatment appears safe and effective, "there's always the possibility that unknown infectious agents could be transmitted this way, " Hohmann says. "We screen these people to be as healthy as we can determine in 2014, but who knows? "